Transcription of human endogenous retroviral long terminal repeat (LTR) sequence in a lung cancer cell line

Naohiro Tomita, Akira Horii, Sadayuki Doi, Hideoki Yokouchi, Michio Ogawa, Takesada Mori, Kenichi Matsubara

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The human genome carries several endogenous retroviral sequences. One of them that we named 'HERV-A', carries almost the complete sequence of the long terminal repeat (LTR), and is located in the 5′ region of the amylase genes (M.Emi, A.Horii, N.Tomita, T.Nishide, M.Ogawa, T.Mori and K.Matsubara, Gene 62: 229-235, 1988). Using this sequence as a probe, we found a 1.4 kb LTR transcript(s) in a lung cancer cell line. No corresponding transcript was observed in control cells. Two partial, but different cDNA clones were obtained, and each one was found to be a transcript starting within human sequences at 5′ upstream from the LTR and ending within the LTR sequence.

本文言語English
ページ(範囲)1-10
ページ数10
ジャーナルBiochemical and biophysical research communications
166
1
DOI
出版ステータスPublished - 1990 1 15

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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