Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord

Masaaki Kitada, David H. Rowitch

研究成果: Article査読

105 被引用数 (Scopus)

抄録

Oligodendrocytes and their precursors serve critical roles in the maintenance of neurological function. Although activity of the transcription factors (TFs) Olig1, Olig2, Sox10, and Nkx2.2 is required during early oligodendrocyte development, their later expression in adult central nervous system is rather poorly characterized. Here we have analyzed coexpression patterns of these transcriptional proteins in the mouse cervical spinal cord. Our findings indicate that TF coexpression patterns describe heterogeneity in adult oligodendroglial populations (1) in distinct sub-regions of grey and white matter and (2) with respect to level of maturation from proliferating precursors to myelinating oligodendrocytes. Our findings suggest that TF co-expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia.

本文言語English
ページ(範囲)35-46
ページ数12
ジャーナルGlia
54
1
DOI
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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