Toxic effects of selenodiglutathione on pregnant mice

Junzo Yonemoto; Tetsuro Hongo; Tsuguyoshi Suzuki; Akira Naganuma; Nobumasa Imura

doi:10.1016/0378-4274(84)90220-0

Toxic effects of selenodiglutathione on pregnant mice

Junzo Yonemoto, Tetsuro Hongo, Tsuguyoshi Suzuki, Akira Naganuma, Nobumasa Imura

研究成果: Article › 査読

9 被引用数 (Scopus)

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A single dose of selenodiglutathione (GSSeSG) or sodium selenite (SS) was injected i.v. into pregnant CD-1 mice on day 12 of gestation at dosages varying from 16.4-32.0 μmol/kg body weight. Dose-dependent elevation of maternal death rates was observed for both treatments, and the slope of the dose-response curve was significantly steeper following GSSeSG treatment. However, fetotoxic effects were not different between the treatments.

本文言語	English
ページ（範囲）	35-39
ページ数	5
ジャーナル	Toxicology Letters
巻	21
号	1
DOI	https://doi.org/10.1016/0378-4274(84)90220-0
出版ステータス	Published - 1984 4月
外部発表	はい

ASJC Scopus subject areas

毒物学

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10.1016/0378-4274(84)90220-0

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title = "Toxic effects of selenodiglutathione on pregnant mice",

abstract = "A single dose of selenodiglutathione (GSSeSG) or sodium selenite (SS) was injected i.v. into pregnant CD-1 mice on day 12 of gestation at dosages varying from 16.4-32.0 μmol/kg body weight. Dose-dependent elevation of maternal death rates was observed for both treatments, and the slope of the dose-response curve was significantly steeper following GSSeSG treatment. However, fetotoxic effects were not different between the treatments.",

keywords = "Selenite, fetotoxicity, maternal death, pregnant mice, selenodiglutathione, stillbirth",

author = "Junzo Yonemoto and Tetsuro Hongo and Tsuguyoshi Suzuki and Akira Naganuma and Nobumasa Imura",

year = "1984",

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doi = "10.1016/0378-4274(84)90220-0",

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T1 - Toxic effects of selenodiglutathione on pregnant mice

AU - Yonemoto, Junzo

AU - Hongo, Tetsuro

AU - Suzuki, Tsuguyoshi

AU - Naganuma, Akira

AU - Imura, Nobumasa

PY - 1984/4

Y1 - 1984/4

N2 - A single dose of selenodiglutathione (GSSeSG) or sodium selenite (SS) was injected i.v. into pregnant CD-1 mice on day 12 of gestation at dosages varying from 16.4-32.0 μmol/kg body weight. Dose-dependent elevation of maternal death rates was observed for both treatments, and the slope of the dose-response curve was significantly steeper following GSSeSG treatment. However, fetotoxic effects were not different between the treatments.

AB - A single dose of selenodiglutathione (GSSeSG) or sodium selenite (SS) was injected i.v. into pregnant CD-1 mice on day 12 of gestation at dosages varying from 16.4-32.0 μmol/kg body weight. Dose-dependent elevation of maternal death rates was observed for both treatments, and the slope of the dose-response curve was significantly steeper following GSSeSG treatment. However, fetotoxic effects were not different between the treatments.

KW - Selenite

KW - fetotoxicity

KW - maternal death

KW - pregnant mice

KW - selenodiglutathione

KW - stillbirth

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JO - Toxicology Letters

JF - Toxicology Letters

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Toxic effects of selenodiglutathione on pregnant mice

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