Towards dynamical network biomarkers in neuromodulation of episodic migraine

Markus A. Dahlem, Sebastian Rode, Arne May, Naoya Fujiwara, Yoshito Hirata, Kazuyuki Aihara, Jürgen Kurths

研究成果: Review article査読

19 被引用数 (Scopus)

抄録

Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.

本文言語English
ページ(範囲)282-294
ページ数13
ジャーナルTranslational Neuroscience
4
3
DOI
出版ステータスPublished - 2013 9月
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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