Toward understanding the role of G-protein signaling

Ryoji Kise, Yuki Ono, Kouki Kawakami, Asuka Inoue

研究成果: Review article査読

抄録

G-protein–coupled receptors (GPCRs) regulate many facets of homeostasis by sensing extracellular signaling molecules. To exert a plethora of roles, GPCRs use divergent and intricate signaling networks. To better understand the role of GPCR signaling, it is an important goal to identify the contribution of every signal transducer and its effectors. Recent advances in methodologies have provided an unprecedented opportunity to characterize many aspects of GPCR signaling, including GPCR–G-protein coupling, selective activation of specific pathways, and the physiological roles of GPCR signaling. Taking advantage of their versatile properties, several methods have been used to generate extensive data sets comparing signaling through a large set of GPCRs. Here, we review recent progress in methodologies to dissect intricate GPCR signaling and discuss future directions of research on GPCR signaling.

本文言語English
ページ(範囲)51-55
ページ数5
ジャーナルCurrent Opinion in Endocrine and Metabolic Research
16
DOI
出版ステータスPublished - 2021 2

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学

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