Toward the synthesis of phomoidride D

Graham K. Murphy, Tatsuya Shirahata, Naoto Hama, Aaron Bedermann, Ping Dong, Travis C. McMahon, Barry M. Twenter, David A. Spiegel, Ivar M. McDonald, Nobuaki Taniguchi, Munenori Inoue, John L. Wood

研究成果: Article査読

14 被引用数 (Scopus)

抄録

An efficient and highly stereoselective approach toward the phomoidride family of natural products is described. The carbocyclic core structure was assembled using a tandem phenolic oxidation/Diels-Alder cycloaddition and a tandem 5-exo-trig/5-exo-trig radical cyclization to deliver an isotwistane intermediate that, upon a late-stage xanthate-initiated Grob fragmentation, furnishes the requisite bicyclo[4.3.1]decene.

本文言語English
ページ(範囲)477-489
ページ数13
ジャーナルJournal of Organic Chemistry
78
2
DOI
出版ステータスPublished - 2013 1 18

ASJC Scopus subject areas

  • 有機化学

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