Toward a total synthesis of amphidinolide N: convergent synthesis of the C1–C13 segment

Atsushi Toyoshima; Makoto Sasaki

doi:10.1016/j.tetlet.2016.06.107

Toward a total synthesis of amphidinolide N: convergent synthesis of the C1–C13 segment

Atsushi Toyoshima, Makoto Sasaki

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

A convergent synthesis of the C1–C13 segment of amphidinolide N, a potent cytotoxic marine macrolide isolated from the dinoflagellate Amphidinium sp., was achieved. The key features of the synthesis involve vinylogous Mukaiyama and Evans aldol reactions to form the C1–C7 and C8–C13 fragments, and convergent union of the two fragments by means of an aldol reaction to construct the C1–C13 segment.

本文言語	English
ページ（範囲）	3532-3534
ページ数	3
ジャーナル	Tetrahedron Letters
巻	57
号	31
DOI	https://doi.org/10.1016/j.tetlet.2016.06.107
出版ステータス	Published - 2016 1 1

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2016.06.107

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引用スタイル

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