Toward a total synthesis of amphidinolide N: convergent synthesis of the C1–C13 segment

Atsushi Toyoshima, Makoto Sasaki

    研究成果: Article査読

    5 被引用数 (Scopus)

    抄録

    A convergent synthesis of the C1–C13 segment of amphidinolide N, a potent cytotoxic marine macrolide isolated from the dinoflagellate Amphidinium sp., was achieved. The key features of the synthesis involve vinylogous Mukaiyama and Evans aldol reactions to form the C1–C7 and C8–C13 fragments, and convergent union of the two fragments by means of an aldol reaction to construct the C1–C13 segment.

    本文言語English
    ページ(範囲)3532-3534
    ページ数3
    ジャーナルTetrahedron Letters
    57
    31
    DOI
    出版ステータスPublished - 2016 1 1

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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