Total synthesis of terfestatins a and B

Shun Sugawara, Yasuhiro Meguro, Shuntaro Sato, Masaru Enomoto, Yusuke Ogura, Shigefumi Kuwahara

研究成果: Article査読

抄録

Terfestatin A, a specific inhibitor of auxin signaling, has been synthesized from a known aromatic aldehyde in 21% overall yield via five steps. The first total synthesis of terfestatin B with potent neuroprotective activity has also been accomplished in eight steps from the same aromatic aldehyde in 30% overall yield through a common intermediate. The key feature of this synthesis is the utilization of the aldehyde functionality of the starting material both as a directing group for regioselective O-protection and as a masked hydroxy group.

本文言語English
論文番号151891
ジャーナルTetrahedron Letters
61
21
DOI
出版ステータスPublished - 2020 5 21

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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