Total synthesis of (-)-rhazinilam using 1,3-dipolar cycloaddition of optically active münchnone intermediate

Kenji Sugimoto, Yuta Miyakawa, Hidetoshi Tokuyama

研究成果: Article査読

17 被引用数 (Scopus)

抄録

A concise stereocontrolled total synthesis of (-)-rhazinilam was achieved by the regioselective 1,3-dipolar cycloaddition of a fully elaborated optically active münchnone intermediate prepared from d-aspartic acid dimethyl ester. The regiochemistry of the 1,3-dipolar cycloaddition of münchnone intermediate to various arylacetylenes was also investigated.

本文言語English
ページ(範囲)3619-3624
ページ数6
ジャーナルTetrahedron
71
22
DOI
出版ステータスPublished - 2015 6 3

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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