Total synthesis of (-)-rhazinilam using 1,3-dipolar cycloaddition of optically active münchnone intermediate

Kenji Sugimoto; Yuta Miyakawa; Hidetoshi Tokuyama

doi:10.1016/j.tet.2014.12.018

Total synthesis of (-)-rhazinilam using 1,3-dipolar cycloaddition of optically active münchnone intermediate

Kenji Sugimoto, Yuta Miyakawa, Hidetoshi Tokuyama

薬学研究科・分子薬科学専攻

研究成果: Article › 査読

16 被引用数 (Scopus)

抄録

A concise stereocontrolled total synthesis of (-)-rhazinilam was achieved by the regioselective 1,3-dipolar cycloaddition of a fully elaborated optically active münchnone intermediate prepared from d-aspartic acid dimethyl ester. The regiochemistry of the 1,3-dipolar cycloaddition of münchnone intermediate to various arylacetylenes was also investigated.

本文言語	English
ページ（範囲）	3619-3624
ページ数	6
ジャーナル	Tetrahedron
巻	71
号	22
DOI	https://doi.org/10.1016/j.tet.2014.12.018
出版ステータス	Published - 2015 6 3

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

文献へのアクセス

10.1016/j.tet.2014.12.018

フィンガープリント「Total synthesis of (-)-rhazinilam using 1,3-dipolar cycloaddition of optically active münchnone intermediate」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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