Total synthesis of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK

Satoru Tamura, Shunsuke Doke, Nobutoshi Murakami

研究成果: Article

8 引用 (Scopus)

抜粋

The first total synthesis of peumusolide A (1) has been achieved by combination of regio- and stereo-selective aluminum-mediated hydroiodination to 2-yn-1-ol and enantioselective reduction of 4-en-1-yn-3-one with the chiral oxazaborolidine as the key reactions. This total synthesis has unequivocally established our proposed absolute structure of 1.

元の言語English
ページ(範囲)8476-8480
ページ数5
ジャーナルTetrahedron
66
発行部数43
DOI
出版物ステータスPublished - 2010 10 23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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