The enantiocontrolled total synthesis of (-)-haouamine B pentaacetate was accomplished via an optically active indane-fused β-lactam, which was prepared by a newly developed Friedel-Crafts reaction. Subsequent cleavage of the β-lactam and an intramolecular McMurry coupling reaction provided the core indane-fused tetrahydropyridine, which led to the elucidation of the structure, as proposed by Trauner and Zubía.
|ジャーナル||Angewandte Chemie - International Edition|
|出版ステータス||Published - 2014 11月 24|
ASJC Scopus subject areas
- 化学 (全般)