Total Synthesis of (+)-CC-1065 Utilizing Ring Expansion Reaction of Benzocyclobutenone Oxime Sulfonate

Taku Imaizumi, Yumi Yamashita, Yuki Nakazawa, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama

研究成果: Article査読

4 被引用数 (Scopus)

抄録

An indole synthesis via ring expansion of benzocyclobutenone oxime sulfonate was developed. Utility of the indole synthesis was demonstrated by the total synthesis of (+)-CC-1065. The middle and right segments were constructed by a sequential ring expansion of the symmetrical benzo-bis-cyclobutenone. The left segment was also constructed via ring expansion of the methyl-substituted benzocyclobutenone oxime sulfonates. After condensation of these three segments, the dienone cyclopropane structure was formed to complete the total synthesis.

本文言語English
ページ(範囲)6185-6189
ページ数5
ジャーナルOrganic letters
21
16
DOI
出版ステータスPublished - 2019 8 16

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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