Total synthesis of avermectin B1a revisited

Shuji Yamashita, Daisuke Hayashi, Aoi Nakano, Yujiro Hayashi, Masahiro Hirama

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by O¯mura and co-workers. Owing to their potent anthelmintic and insecticidal activities, as well as their unique pentacyclic architecture, the avermectin family attracted keen interest from synthetic organic chemists. We have recently completed a more efficient and straightforward total synthesis of avermectin B 1a, as compared with previous syntheses.

本文言語English
ページ(範囲)31-50
ページ数20
ジャーナルJournal of Antibiotics
69
1
DOI
出版ステータスPublished - 2016 1 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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