Total synthesis of aspergillides A, B, and C

Tomohiro Nagasawa, Shigefumi Kuwahara

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

Aspergillides A, B, and C are cytotoxic macrolides produced by the marine-derived fungus Aspergillus ostianus strain TUF 01F313. The unique molecular architectures of the aspergillides featuring 14-membered marocyclic structures embedded with a tetrahydro-or dihydropyran unit have attracted significant attention from the synthetic chemistry community, and thereby various synthetic approaches to these structurally as well as pharmacologically intriguing molecules have been reported by as many as 12 research groups in the past 3 years. This review describes all of the syntheses disclosed to date, focusing mainly on the methodologies employed for the diastereoselective installation of the pyran ring systems..

本文言語English
ページ(範囲)587-613
ページ数27
ジャーナルHeterocycles
85
3
DOI
出版ステータスPublished - 2012 2 27

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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