Total synthesis of (-)-agelastatin A: The application of a sequential sigmatropic rearrangement

Naoto Hama; Tomoki Matsuda; Takaaki Sato; Noritaka Chida

doi:10.1021/ol900799e

Total synthesis of (-)-agelastatin A: The application of a sequential sigmatropic rearrangement

Naoto Hama, Tomoki Matsuda, Takaaki Sato, Noritaka Chida

薬学研究科・分子薬科学専攻

研究成果: Article › 査読

74 被引用数 (Scopus)

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An enantioselective total synthesis of (-)-agelastatin A from (-)-2,3-O-isopropylidene-D-threitol is described. The sequential Overman/Mislow-Evans rearrangement of the allylic bistrichloroimidate is the key step, which efficiently installed a diaminohydroxy group.

本文言語	English
ページ（範囲）	2687-2690
ページ数	4
ジャーナル	Organic letters
巻	11
号	12
DOI	https://doi.org/10.1021/ol900799e
出版ステータス	Published - 2009 6月 18

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol900799e

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abstract = "An enantioselective total synthesis of (-)-agelastatin A from (-)-2,3-O-isopropylidene-D-threitol is described. The sequential Overman/Mislow-Evans rearrangement of the allylic bistrichloroimidate is the key step, which efficiently installed a diaminohydroxy group.",

author = "Naoto Hama and Tomoki Matsuda and Takaaki Sato and Noritaka Chida",

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AU - Chida, Noritaka

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Y1 - 2009/6/18

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AB - An enantioselective total synthesis of (-)-agelastatin A from (-)-2,3-O-isopropylidene-D-threitol is described. The sequential Overman/Mislow-Evans rearrangement of the allylic bistrichloroimidate is the key step, which efficiently installed a diaminohydroxy group.

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Total synthesis of (-)-agelastatin A: The application of a sequential sigmatropic rearrangement

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