Total synthesis and biological assessment of (-)-Exiguolide and analogues

Chemistry

• Total Synthesis 100%
• Tetrahydropyran 66%
• Antiproliferative 33%
• Enantiomer 33%
• Alkene 33%
• Cyclization Reaction 33%
• Structure-Activity Relationship 33%
• Bioassay 33%
• Cross Metathesis 33%
• Occurrence in Nature 33%
• Yamaguchi Esterification 33%
• Julia-Kocienski Olefination 33%
• Length 33%
• Group 33%
• Conjugate 33%
• Point Group C5 33%
• Etherification 33%