Total Syntheses of (+)-T988 B and (+)-T988 C through the AgNTf2-Mediated Coupling of Bromopyrroloindoline with Indole

Soichiro Sato, Azusa Hirayama, Hirofumi Ueda, Hidetoshi Tokuyama

研究成果: Article査読

8 被引用数 (Scopus)

抄録

The total syntheses of (+)-T988 B and (+)-T988 C were accomplished in 19 and 18 steps, respectively, in 20.2 % overall yield. The indole segment was regioselectively introduced at the sterically hindered C10b position through a diastereoselective bromocyclization reaction and a subsequent AgNTf2-mediated Friedel–Crafts reaction. The dithiodioxopiperazine moiety was efficiently constructed through a one-pot radical-mediated C−H bromination/dehydrobromination procedure on the dioxopiperazine ring.

本文言語English
ページ(範囲)54-58
ページ数5
ジャーナルAsian Journal of Organic Chemistry
6
1
DOI
出版ステータスPublished - 2017 1 1

ASJC Scopus subject areas

  • Organic Chemistry

フィンガープリント 「Total Syntheses of (+)-T988 B and (+)-T988 C through the AgNTf<sub>2</sub>-Mediated Coupling of Bromopyrroloindoline with Indole」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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