Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification

Akihiro Tazawa, Ying Ye, Taro Ozaki, Chengwei Liu, Yasushi Ogasawara, Tohru Dairi, Yusuke Higuchi, Nobuo Kato, Katsuya Gomi, Atsushi Minami, Hideaki Oikawa

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The biosynthetic pathway of brassicicenes, derived from the phytopathogen Pseudocercospora fijiensis, was fully reconstituted. Heterologous expression of the eight genes highly expressed in infected leaf tissues generated a new brassicicene derivative as a final product. Together with the characterization of P450 from Alternaria brassicicola, a late stage of the biosynthetic pathway, which generates remarkable structural diversity, has been proposed. Notably, a unique P450 that converts 3 to the structurally distinct 4 and 6 was identified.

本文言語English
ページ(範囲)6178-6182
ページ数5
ジャーナルOrganic letters
20
19
DOI
出版ステータスPublished - 2018 10 5

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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