Topical treatment of pulmonary aspergilloma by antifungals: Relationship between duration of the disease and efficacy of therapy

H. Yamada, S. Kohno, H. Koga, S. Maesaki, M. Kaku

研究成果: Article査読

67 被引用数 (Scopus)

抄録

Twelve patients with aspergilloma were treated with intracavitary or endobronchial administration of antifungals. Patients with successful therapy had significantly shorter mean duration of the disease course (3.6 months) than the less effective group (44.4 months, p<0.01). Minimal inhibitory concentrations of antifungal agents against isolated strains of aspergilli were considerably lower than estimated intracavitary concentrations of the antifungals. A pathologic examination suggested that the old mycetoma was for the most part comprised of dead mycelial cells, against which antifungal agents were not effective. However, clinical improvement was obtained, regardless of the roentgenographic improvement. Our study suggested that early diagnosis and therapy are recommended to achieve better therapeutic effect.

本文言語English
ページ(範囲)1421-1425
ページ数5
ジャーナルChest
103
5
DOI
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

フィンガープリント 「Topical treatment of pulmonary aspergilloma by antifungals: Relationship between duration of the disease and efficacy of therapy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル