Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy

Osamu Hotta, Mariko Miyazaki, Takashi Furuta, Sachiko Tomioka, Shigemi Chiba, Ikuo Horigome, Keishi Abe, Yoshio Taguma

研究成果: Article査読

242 被引用数 (Scopus)

抄録

We conducted a retrospective investigation of renal outcome in 329 patients with immunoglobulin A (IgA) nephropathy with an observation period longer than 36 months (82.3±38.2 months) in our renal unit between 1977 and 1995. Clinical remission, renal progression, and the impact of covariates were estimated by Kaplan-Meier analysis and a Cox regression model. In 157 of 329 patients (48%), disappearance of urinary abnormalities (clinical remission) was obtained. None of these 157 patients showed progressive deterioration, defined as a 50% increase in serum creatinine (Scr) level from baseline, during the observation period. Conversely, in patients without clinical remission, the Kaplan-Meier estimate of probability of progressive deterioration was 21%±5% at 10 years. In the multivariate Cox regression model with 13 independent covariates, initial Scr level, histological score, tonsillectomy, and high-dose methylprednisolone therapy had a significant impact on clinical remission, whereas proteinuria, age, sex, levels of hematuria, blood pressure, conventional steroid therapy, angiotensin-converting enzyme inhibitor therapy, and cyclophosphamide therapy had no significant effect. These findings indicate that interventions aimed at achieving clinical remission have provided encouraging results applicable to managing patients with IgA nephropathy.

本文言語English
ページ(範囲)736-743
ページ数8
ジャーナルAmerican Journal of Kidney Diseases
38
4
DOI
出版ステータスPublished - 2001 10
外部発表はい

ASJC Scopus subject areas

  • 腎臓病学

フィンガープリント

「Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル