Tissue concentrations of estrogens and aromatase immunolocalization in interstitial pneumonia of human lung

Shinji Taniuchi, Fumiyoshi Fujishima, Yasuhiro Miki, Keiko Abe, Yasuhiro Nakamura, Satoko Sato, Atsuko Kasajima, Misaki Fue, Kazuyuki Ishida, Mika Watanabe, Tomohiro Sakakibara, Sumiko Maeda, Takashi Suzuki, Hironobu Sasano

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Interstitial pneumonia (IP) is characterized by various degrees of pulmonary fibrosis and inflammation. Estrogens have been demonstrated to play important roles in physiological and pathological conditions of human lung, but significance of estrogens has remained unknown in human IP. Therefore, we measured estrogen concentrations and immunolocalized aromatase and estrogen receptor β (ERβ) in IP tissues. Estradiol concentration was significantly (2.8-fold) higher in IP than normal lung tissues, and aromatase activity evaluated by estradiol/testosterone ratio was also significantly (7.2-fold) elevated in IP tissues. Aromatase immunoreactivity in alveolar epithelial cells was significantly frequent in IP than normal lung or inflammatory lung disease other than IP, and it was positively associated with ERβ immunoreactivity in these cells of IP. These results suggest that estradiol concentration is locally increased in human IP tissue by aromatase, and increased estrogens may play an important role in the development of IP through ERβ in the alveolar epithelial cells.

本文言語English
ページ(範囲)136-143
ページ数8
ジャーナルMolecular and Cellular Endocrinology
392
1-2
DOI
出版ステータスPublished - 2014 7 5

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学

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