Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

Satoshi Omori, Misato Tsugita, Yasuto Hoshikawa, Masanobu Morita, Fumiya Ito, Shin Ichiro Yamaguchi, Qilin Xie, Osamu Noyori, Tomoya Yamaguchi, Ayato Takada, Tatsuya Saitoh, Shinya Toyokuni, Hisaya Akiba, Shigekazu Nagata, Kengo Kinoshita, Masafumi Nakayama

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Needle-like multi-walled carbon nanotubes (MWCNTs) are engulfed by macrophages, which cause inflammation and asbestosis-like pathogenesis in rodents; however, how macrophages recognize MWCNTs remains unclear. Omori et al. demonstrate that Tim4 recognizes MWCNTs through aromatic-aromatic interactions and mediates macrophage phagocytosis leading to granulomas.

本文言語English
論文番号108734
ジャーナルCell Reports
34
6
DOI
出版ステータスPublished - 2021 2 9

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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