Three-dimensional Simulation of Blood Flow in Malaria Infection

Yohsuke Imai, H. Kondo, Takuji Ishikawa, C. T. Lim, K. Tsubota, Takami Yamaguchi

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.

本文言語English
ホスト出版物のタイトル13th International Conference on Biomedical Engineering - ICBME 2008
ページ2244-2247
ページ数4
DOI
出版ステータスPublished - 2009 12 1
イベント13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
継続期間: 2008 12 32008 12 6

出版物シリーズ

名前IFMBE Proceedings
23
ISSN(印刷版)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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