Three-dimensional coupled photon and bio-heat transport simulation for laser-induced photothermal therapy

Takuma Kogawa, Yousuke Nakamura, Soma Taniguchi, Hisashi Nakajima, Junnosuke Okajima, Atsuki Komiya, Shigenao Maruyama, Atsushi Sakurai

研究成果: Article査読


Recently, selective heating techniques by laser therapy have been proposed. Among them, laser therapy adopting metallic nanoparticles has garnered att ention. By injecting metallic nanoparticles inside a tissue, high absorption can be achieved by the local surface plasmonic resonance at the surface of the nanoparticle. In particular, gold nanorods exhibit signifi cantly high resonance against laser and their eff ectiveness has been investigated experimentally. However, the modeling of laser therapy by gold nanorods is limited, and a quantitative numerical simulation is required to further investigate the possibility of eff ective heating by gold nanorods. To investigate the eff ectiveness of selective heating by laser therapy with gold nanorods, a three-dimensional calculation of laser therapy is performed in this study. To model the thermal conduction and propagation of laser inside a tissue, the Pennes bio-heat transfer equation is applied. The radiative heat transfer is calculated using the radiation element method. The dispersion eff ect of gold nanorod injection is considered. Comparing the thermal damage between gold nanorod injection and noninjection cases, the performance of selective heating by gold nanorods is evaluated. Furthermore, the eff ect of gold nanorod injection location on the thermal damage is discussed. Numerical calculation results indicate that gold nanorod injection enables selective heating against the target as well as noninvasive heating on the tissue surface. Furthermore, the heating depth can be controlled by changing the injection location appropriately.

ジャーナルHeat Transfer Research
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 凝縮系物理学
  • 機械工学
  • 流体および伝熱


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