Three Cases of Clinical or Preclinical Cushing's Syndrome due to Adrenocorticotropic Hormone-Independent Bilateral Adrenocortical Macronodular Hyperplasia: Pituitary-Adrenocortical Function and Immunohistochemistry

Osamu Murakami, Fumitoshi Satoh, Kazuhiro Takahashi, Kazuhito Totsune, Masahiko Sone, Makoto Ohneda, Keishi Abe, Takashi Suzuki, Hironobu Sasano, Toraichi Mouri

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We performed pituitary-adrenocortical function test and analysis of plasma steroids in three cases of adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia, and examined the plasma cortisol response to meal and oral glucose in two cases. On pathological examination, nodules were mainly composed of clear cells and some nests of compact cells were observed. Immunohistochemistry of steroidogenic enzymes showed positive P-450C17 only in the compact cells and positive 3β-hydroxysteroid dehydrogenase only in the clear cells. These cases were similar to clinical or preclinical Cushing's syndrome due to adenoma in both pituitary-adrenocortical function and plasma steroid patterns, but different from adenoma cases in the distribution of steroidogenic enzymes.

本文言語English
ページ(範囲)1074-1081
ページ数8
ジャーナルInternal Medicine
34
11
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • 内科学

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「Three Cases of Clinical or Preclinical Cushing's Syndrome due to Adrenocorticotropic Hormone-Independent Bilateral Adrenocortical Macronodular Hyperplasia: Pituitary-Adrenocortical Function and Immunohistochemistry」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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