Therapeutic effect of anti-TNF-α antibody and levofloxacin (LVFX) in a mouse model of enterohemorrhagic Escherichia coli 0157 infection

Emiko Isogai, Hiroshi Isogai, Kimiharu Hirose, Toru Kubota, Koichi Kimura, Nobuhiro Fujii, Shunji Hayashi, Koichi Takeshi, Keiji Oguma

研究成果: Article

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The ability of an anti-TNF-α antibody to confer protection against enterohaemorrhagic Escherichia coli (EHEC) O157 was investigated in germfree IQI mice. The use of an antibiotic levofloxacin (LVFX) alone or with the antibody was also studied. Protection included an increase in survival rate. Treatment with the anti-TNF-α antibody inhibited the histological signs associated with EHEC infection but did not prevent the colonization of EHEC or production of Shiga toxin (Stx). No clinical signs were observed and EHEC was completely eliminated in the mouse model receiving both anti-TNF-α antibody and LVFX. Anti-TNF-α antibody suppressed inflammatory cytokine response in the mouse kidney and brain by EHEC infection.

元の言語English
ページ(範囲)217-231
ページ数15
ジャーナルComparative Immunology, Microbiology and Infectious Diseases
24
発行部数4
DOI
出版物ステータスPublished - 2001 1 1

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • veterinary(all)
  • Infectious Diseases

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