The vasohibin family: A negative regulatory system of angiogenesis genetically programmed in endothelial cells

Yasufumi Sato, Hikaru Sonoda

研究成果: Short survey査読

56 被引用数 (Scopus)

抄録

Biological phenomena are under the precise control by the genome. For the regulation of angiogenesis, proangiogenic genes such as VEGFs and angiopoietins are highly conserved, act specifically on endothelial cells, and play a fundamental role. In this sense, nature should prepare specific antiangiogenic genes as well. However, this counterpart of genomic regulation of angiogenesis remains to be established. We recently isolated a novel endothelium-derived angiogenesis inhibitor and named it vasohibin. Vasohibin is dominantly expressed in endothelial cells, induced by the stimulation with VEGF or FGF-2, and selectively affects on endothelial cells and inhibits angiogenesis. Although the mechanism of how vasohibin inhibits angiogenesis remains to be elucidated, our discovery of vasohibin as an endothelium-derived VEGF-inducible angiogenesis inhibitor should shed light on the genomic basis of the negative regulation of angiogenesis.

本文言語English
ページ(範囲)37-41
ページ数5
ジャーナルArteriosclerosis, thrombosis, and vascular biology
27
1
DOI
出版ステータスPublished - 2007 1月

ASJC Scopus subject areas

  • 循環器および心血管医学

フィンガープリント

「The vasohibin family: A negative regulatory system of angiogenesis genetically programmed in endothelial cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル