The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification

Jun Unno, Atsushi Kanno, Atsushi Masamune, Atsuko Kasajima, Fumiyoshi Fujishima, Kazuyuki Ishida, Shin Hamada, Kiyoshi Kume, Kazuhiro Kikuta, Morihisa Hirota, Fuyuhiko Motoi, Michiaki Unno, Toru Shimosegawa

研究成果: Article査読

36 被引用数 (Scopus)

抄録

BACKGROUND: We assessed the controversial topic of using 22-gauge needles in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis and evaluation of Ki67 labeling indices (Ki67LI) of pancreatic neuroendocrine tumors (pNET).

METHODS: Thirty-eight patients with pNET who underwent EUS-FNA between January 1, 2008 and December 31, 2012 were enrolled in this study. When available, the Ki67LI and WHO classifications obtained by EUS-FNA and surgical resection were compared.

RESULTS: EUS-FNA with a 22-gauge needle acquired sufficient histological sample to correctly diagnose pNET in 35 cases (92.1%). Both EUS-FNA and surgical histological specimens were available for 19 cases, and grading classes of the 2 procedures were consistent in 17 cases (89.5%) according to the WHO classification based on the Ki67LI. Tumor size was associated with a difference in the Ki67LI between the 2 procedures, although the Ki67LI was almost completely consistent for tumors less than 18 mm in size.

CONCLUSIONS: EUS-FNA with a 22-gauge needle is a safe and highly accurate technique for the diagnosis of pNET. There was a clear correlation between the Ki67LI of histological specimens acquired by EUS-FNA and surgery. EUS-FNA with a 22-gauge needle is useful to predict the WHO classification of pNET.

本文言語English
ページ(範囲)1367-1374
ページ数8
ジャーナルScandinavian journal of gastroenterology
49
11
DOI
出版ステータスPublished - 2014 11 1

ASJC Scopus subject areas

  • 消化器病学

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