The T3b gene promoter directs intestinal epithelial cell-specific expression in transgenic mice

Hiroyuki Aihara, Nobuo Hiwatashi, Shinji Kumagai, Yuhichi Obata, Tooru Shimosegawa, Takayoshi Toyota, Jun Ichi Miyazaki

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Although a few promoters that direct intestinal epithelial cell-specific expression in transgenic animals have been reported, they are not necessarily appropriate for transgenic studies in terms of activity and tissue specificity. Here, we examined the tissue specificity of transgene expression directed by the 2.8-kb promoter region of the T3b gene, which encodes one of the non-classical major histocompatibility complex class I molecules. The transgene was expressed exclusively in the epithelial cells of the small and large intestines at high levels. The results indicate that the T3b promoter is useful for directing transgene expression specifically in intestinal epithelial cells.

本文言語English
ページ(範囲)185-188
ページ数4
ジャーナルFEBS Letters
463
1-2
DOI
出版ステータスPublished - 1999 12月 10
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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