The synthesis of o‐ and p‐[¹⁸F]fluorobenzyl bromides and their application to the prepatation of labeled neuroleptics

The syntheses of o‐ and p‐ [¹⁸F]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde via a three step synthesis that exhibited good yield. The preparation of [¹⁸F]fluororinated analog of a benzamide neuroleptic, cis‐N‐[(2RS, 3RS)‐1‐[¹⁸F]fluorobenzyl‐2‐methylpyrrolidin‐3‐yl] ‐5‐chloro‐2‐methoxy‐4‐methylaminobenzamide, via N‐benzylation with the synthons was also mentioned.