The syntheses of o‐ and p‐ [18F]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde via a three step synthesis that exhibited good yield. The preparation of [18F]fluororinated analog of a benzamide neuroleptic, cis‐N‐[(2RS, 3RS)‐1‐[18F]fluorobenzyl‐2‐methylpyrrolidin‐3‐yl] ‐5‐chloro‐2‐methoxy‐4‐methylaminobenzamide, via N‐benzylation with the synthons was also mentioned.
|ジャーナル||Journal of Labelled Compounds and Radiopharmaceuticals|
|出版ステータス||Published - 1991 4月|
ASJC Scopus subject areas