The synthesis of o‐ and p‐[18F]fluorobenzyl bromides and their application to the prepatation of labeled neuroleptics

Kentaro Hatano, Tatsuo Ido, Ren Iwata

    研究成果: Article査読

    17 被引用数 (Scopus)

    抄録

    The syntheses of o‐ and p‐ [18F]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde via a three step synthesis that exhibited good yield. The preparation of [18F]fluororinated analog of a benzamide neuroleptic, cis‐N‐[(2RS, 3RS)‐1‐[18F]fluorobenzyl‐2‐methylpyrrolidin‐3‐yl] ‐5‐chloro‐2‐methoxy‐4‐methylaminobenzamide, via N‐benzylation with the synthons was also mentioned.

    本文言語English
    ページ(範囲)373-380
    ページ数8
    ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
    29
    4
    DOI
    出版ステータスPublished - 1991 4月

    ASJC Scopus subject areas

    • 分析化学
    • 生化学
    • 放射線学、核医学およびイメージング
    • 創薬
    • 分光学
    • 有機化学

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