TY - JOUR
T1 - The sixth nationwide epidemiological survey of chronic pancreatitis in Japan
AU - Hirota, Morihisa
AU - Shimosegawa, Tooru
AU - Masamune, Atsushi
AU - Kikuta, Kazuhiro
AU - Kume, Kiyoshi
AU - Hamada, Shin
AU - Kihara, Yasuyuki
AU - Satoh, Akihiko
AU - Kimura, Kenji
AU - Tsuji, Ichiro
AU - Kuriyama, Shinichi
N1 - Funding Information:
This work was supported by a Grant-in-Aid to the Research Committee of the Intractable Pancreatic Diseases (Chairman, Tooru Shimosegawa), provided from the Ministry of Health, Labour and Welfare of Japan .
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Objectives: A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan. Methods: Two sequential surveys were conducted. In the first survey, both the prevalence and incidence of CP in Japan in 2007 were estimated by a questionnaire, which was mailed to 3027 randomly chosen Japanese facilities. In the second survey, the second questionnaire was then mailed to 1110 facilities selected by the first survey to clarify the clinicoepidemiological features of the patients. Results: The estimated annual prevalence of CP was 36.9 per 100,000; 53.2 in males and 21.2 in females. The estimated annual incidence was 11.9 per 100,000. The prevalence and the incidence of CP gradually increased in Japan as compared to former surveys. The sex ratio (male/female) of definitive and probable CP patientswas 4.5, with a mean age of 59.4 years; 59.2 years in males and 60.2 years in females. Alcoholic (69.7%) was most the common and idiopathic (21.0%) was the second most common cause of CP. The proportion of alcoholic CP increased as compared to the 55.5% found in 1994. The clinical features of overall Japanese patients with CP were: abdominal pain (60.6%), malabsorbtion (12.2%), diabetes mellitus (39.7%) and pancreatolithiasis (75.7%). Alcoholic patients were characterized by high morbidity as compared to nonalcoholic patients: abdominal pain (alcoholic 65.0% vs nonalcoholic 53.0%, p < 0.0001), diabetes mellitus (44.8% vs 31.4%, p < 0.0001) and pancreatolithiasis (84.0% vs 60.8%, p < 0.0001). Conclusion: The prevalence and the incidence of CP, especially alcoholic CP, have been increasing in Japan.
AB - Objectives: A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan. Methods: Two sequential surveys were conducted. In the first survey, both the prevalence and incidence of CP in Japan in 2007 were estimated by a questionnaire, which was mailed to 3027 randomly chosen Japanese facilities. In the second survey, the second questionnaire was then mailed to 1110 facilities selected by the first survey to clarify the clinicoepidemiological features of the patients. Results: The estimated annual prevalence of CP was 36.9 per 100,000; 53.2 in males and 21.2 in females. The estimated annual incidence was 11.9 per 100,000. The prevalence and the incidence of CP gradually increased in Japan as compared to former surveys. The sex ratio (male/female) of definitive and probable CP patientswas 4.5, with a mean age of 59.4 years; 59.2 years in males and 60.2 years in females. Alcoholic (69.7%) was most the common and idiopathic (21.0%) was the second most common cause of CP. The proportion of alcoholic CP increased as compared to the 55.5% found in 1994. The clinical features of overall Japanese patients with CP were: abdominal pain (60.6%), malabsorbtion (12.2%), diabetes mellitus (39.7%) and pancreatolithiasis (75.7%). Alcoholic patients were characterized by high morbidity as compared to nonalcoholic patients: abdominal pain (alcoholic 65.0% vs nonalcoholic 53.0%, p < 0.0001), diabetes mellitus (44.8% vs 31.4%, p < 0.0001) and pancreatolithiasis (84.0% vs 60.8%, p < 0.0001). Conclusion: The prevalence and the incidence of CP, especially alcoholic CP, have been increasing in Japan.
KW - Chronic pancreatitis
KW - Etiology
KW - Incidence
KW - Nationwide survey
KW - Prevalence
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U2 - 10.1016/j.pan.2012.02.005
DO - 10.1016/j.pan.2012.02.005
M3 - Article
C2 - 22487515
AN - SCOPUS:84862236125
VL - 12
SP - 79
EP - 84
JO - Pancreatology
JF - Pancreatology
SN - 1424-3903
IS - 2
ER -