The role of Rho-kinase pathway on PAH

Yoshihiro Fukumoto, Hiroaki Shimokawa

研究成果: Review article査読

1 被引用数 (Scopus)


Anticoagulant agents, vasodilators, and lung transplantation are currently used for the treatment of pulmonary arterial hypertension (PAH); however, more effective treatment needs to be developed. Rho-kinase-mediated pathway plays an important role in various cellular functions, such as vascular smooth muscle hyperconstriction or cell adhesion and motility. We have demonstrated that Rho-kinase is activated in animal models of PAH associated with enhanced pulmonary vasoconstricting and proliferating responses, impaired endothelial vasodilator functions, and pulmonary remodeling and that intravenous fasudil, a selective Rho-kinase inhibitor, exerts acute pulmonary vasodilator effects in patients with severe PAH. Our findings indicate that Rho-kinase is a novel and important therapeutic target of PAH and that Rho-kinase inhibitors are a promising new class of drugs for the disorder.

ジャーナルNippon rinsho. Japanese journal of clinical medicine
出版ステータスPublished - 2008 11月

ASJC Scopus subject areas

  • 医学(全般)


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