The role of ATP-sensitive potassium channels in regulating coronary microcirculation

T. Komaru, H. Kanatsuka, K. Dellsperger, T. Takishima

研究成果: Article

17 引用 (Scopus)

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The ATP-sensitive potassium channel (K+(ATP) channel) is known to exist in blood vessels and to regulate vascular tone. We examined the role of this channel in coronary arteriolar vasomotion during coronary autoregulation, ischemia, reactive hyperemia and endothelium-dependent response by acetylcholine in vivo. Experiments were performed with anesthetized open- chest dogs. Coronary arterioles were directly observed in situ by means of a floating objective system or a stroboscropic epi-illumination system synchronized with cardiac motion. Small arterioles less than 100 μm in internal diameter dilated in response to reduction in perfusion pressure (perfusion pressure: 60, 40, 25 mm Hg). Glibenclamide, a selective blocker of the K+(ATP) channel, reversed the dilation. Reactive hyperemia produced by 20-second occlusion of the left anterior descending coronary artery resulted in arteriolar dilation, the magnitude of which was greater in smaller arterioles than in larger ones. Glibenclamide significantly inhibited the dilation in both large and small arterioles. Acetylcholine (ACh) produced dilation in arterioles of all sizes. NG-monomethyl L-arginine, a competitive inhibitor of nitric oxide synthesis, abolished the dilation of large arterioles, but failed to abolish the dilation in small arterioles. Glibenclamide, however, did not have any additional inhibitory effect on ACh- induced arteriolar dilation. Thus, we conclude that the K+(ATP) channel plays an important role in coronary microvascular vasomotion during autoregulation, ischemia and reactive hyperemia, but not during endothelium- dependent vasodilation induced by ACh in vivo.

元の言語English
ページ(範囲)371-380
ページ数10
ジャーナルBiorheology
30
発行部数5-6
DOI
出版物ステータスPublished - 1993 1 1

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Komaru, T., Kanatsuka, H., Dellsperger, K., & Takishima, T. (1993). The role of ATP-sensitive potassium channels in regulating coronary microcirculation. Biorheology, 30(5-6), 371-380. https://doi.org/10.3233/BIR-1993-305-608