The role of androgen under normal and pathological conditions in sebaceous glands: The possibility of target therapy

Abdullah Azmahani, Yasuhiro Nakamura, Keely M. McNamara, Hironobu Sasano

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous disorders present evidence that androgen receptor may be a sensitive marker of sebaceous differentiation. It has been previously suggested that AR and steroidogenic enzymes immunohistochemistry may be useful particularly in identifying poorly sebaceous carcinoma. This review will provide an overview of the AR functions in the sebaceous glands and discussion of the therapeutic targets in acne and carcinoma.

本文言語English
ページ(範囲)311-319
ページ数9
ジャーナルCurrent Molecular Pharmacology
9
4
DOI
出版ステータスPublished - 2016 11 1

ASJC Scopus subject areas

  • 分子医療
  • 薬理学
  • 創薬

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