The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion

Yoshiaki Itoigawa, Osamu Suzuki, Hirotaka Sano, Takahisa Anada, Takuto Handa, Taku Hatta, Yoshiyuki Kuwahara, Atsushi Takahashi, Yushi Ezoe, Kazuo Kaneko, Eiji Itoi

研究成果: Article

5 被引用数 (Scopus)

抄録

Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.

本文言語English
ページ(範囲)e175-e184
ジャーナルJournal of Shoulder and Elbow Surgery
24
7
DOI
出版ステータスPublished - 2015 7 1

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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