The role of 17βHSDs in breast tissue and breast cancers

Keely May Mcnamara, Hironobu Sasano

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

The family of seventeen beta hydroxysteroid dehydrogenase enzymes has a long and diverse history in breast and breast cancer research. Given the known dependence of the breast on steroid signalling and intracrine steroid metabolism these enzymes are considered to be essential local fine tuners of overall steroid balance in the tissue. This review will cover the current state of knowledge regarding the expression, clinical effect and biological regulation of enzymes in both cancerous and normal states. In addition we will also cover the current state of knowledge regarding 17βHSD actions in the often neglected adipose and stromal components of tumours.

本文言語English
ページ(範囲)32-44
ページ数13
ジャーナルMolecular and Cellular Endocrinology
489
DOI
出版ステータスPublished - 2019 6 1

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学

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