The relationship between advanced glycation end products and ocular circulation in type 2 diabetes

Kazuki Hashimoto, Hiroshi Kunikata, Masayuki Yasuda, Azusa Ito, Naoko Aizawa, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Yoshimasa Takano, Koji M. Nishiguchi, Hideki Katagiri, Toru Nakazawa

研究成果: Article査読

15 被引用数 (Scopus)


Aims To determine whether skin autofluorescence (SAF) and serum pentosidine, biomarkers of advanced glycation end products (AGEs), were associated with ocular microcirculation in type 2 diabetes patients with early diabetic retinopathy (DR). Methods This study included 46 eyes of 46 type 2 diabetes patients with no DR or non-proliferative DR. SAF was measured with an autofluorescence reader. Optic nerve head (ONH) microcirculation, represented by mean blur rate (MBR), was measured with laser speckle flowgraphy. Overall MBR, vascular MBR, and tissue MBR were calculated in software. MBR, SAF, pentosidine levels, and clinical findings, including central macular thickness (CMT), were then compared. Results SAF in the diabetes patients was correlated with age (P = 0.018). Serum pentosidine was correlated with age, vascular MBR and tissue MBR (P = 0.046, P = 0.035, and P = 0.01, respectively). CMT was correlated with tissue MBR (P = 0.016), but not with vascular MBR or overall MBR. Separate multiple regression analyses of independent contributing factors revealed that age, SAF, serum pentosidine, duration of diabetes, and pulse rate contributed to tissue MBR (P = 0.041, P = 0.046, P = 0.022, P = 0.011 and P = 0.036, respectively), while SAF, HbA1c, pulse rate, tissue MBR, diastolic blood pressure, and creatinine contributed to CMT (P = 0.005, P = 0.039, P < 0.001, P < 0.001, P = 0.022 and P = 0.001, respectively). Conclusions Tissue MBR may be closely related to AGE levels and CMT in type 2 diabetes patients with early DR, suggesting that ocular circulation might be potential early biomarkers of DR.

ジャーナルJournal of Diabetes and Its Complications
出版ステータスPublished - 2016 9 1

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学


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