The regulation of oxytocin receptor gene expression during adipogenesis

K. J. Yi, K. H. So, Y. Hata, Y. Suzuki, D. Kato, Kouichi Watanabe, H. Aso, Y. Kasahara, Katsuhiko Nishimori, C. Chen, Kazuo Katoh, S. G. Roh

研究成果: Article査読

37 被引用数 (Scopus)


Although it has been reported that oxytocin stimulates lipolysis in adipocytes, changes in the expression of oxytocin receptor (OTR) mRNA in adipogenesis are still unknown. The present study aimed to investigate the expression of OTR mRNA during adipocyte differentiation and fat accumulation in adipocytes. OTR mRNA was highly expressed in adipocytes prepared from mouse adipose tissues compared to stromal-vascular cells. OTR mRNA expression was increased during the adipocyte differentiation of 3T3-L1 cells. OTR expression levels were higher in subcutaneous and epididymal adipose tissues of 14-week-old male mice compared to 7-week-old male mice. Levels of OTR mRNA expression were higher in adipose tissues at four different sites of mice fed a high-fat diet than in those of mice fed a normal diet. The OTR expression level was also increased by refeeding for 4 h after fasting for 16 h. Oxytocin significantly induced lipolysis in 3T3-L1 adipocytes. In conclusion, a new regulatory mechanism is demonstrated for oxytocin to control the differentiation and fat accumulation in adipocytes via activation of OTR as a part of the hypothalamic-pituitary-adipose axis.

ジャーナルJournal of Neuroendocrinology
出版ステータスPublished - 2015 5月 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学
  • 内分泌系および自律システム
  • 細胞および分子神経科学


「The regulation of oxytocin receptor gene expression during adipogenesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。