The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia

Kousuke Yoshinaga, Hironobu Sasano, Toru Furukawa, Hiromitsu Yamakawa, Michihiro Yuki, Shinji Sato, Akira Yajima, Akira Horii

研究成果: Article査読

37 被引用数 (Scopus)

抄録

To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability mutations in the PTEN, TGF βRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.

本文言語English
ページ(範囲)985-990
ページ数6
ジャーナルJapanese Journal of Cancer Research
89
10
DOI
出版ステータスPublished - 1998 10月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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