TY - JOUR
T1 - The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia
AU - Yoshinaga, Kousuke
AU - Sasano, Hironobu
AU - Furukawa, Toru
AU - Yamakawa, Hiromitsu
AU - Yuki, Michihiro
AU - Sato, Shinji
AU - Yajima, Akira
AU - Horii, Akira
PY - 1998/10
Y1 - 1998/10
N2 - To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability mutations in the PTEN, TGF βRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.
AB - To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability mutations in the PTEN, TGF βRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.
KW - BAX
KW - Endometrial hyperplasia
KW - IGFIIR
KW - MSI
KW - PTEN
UR - http://www.scopus.com/inward/record.url?scp=0031784498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031784498&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.1998.tb00485.x
DO - 10.1111/j.1349-7006.1998.tb00485.x
M3 - Article
C2 - 9849574
AN - SCOPUS:0031784498
VL - 89
SP - 985
EP - 990
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 10
ER -
