The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells

Takahiko Sasaki, Mutsuo Yamaya, Hiroyasu Yasuda, Daisuke Inoue, Mitsuhiro Yamada, Hiroshi Kubo, Hidekazu Nishimura, Hidetada Sasaki

研究成果: Article査読

47 被引用数 (Scopus)

抄録

To examine the effects of lansoprazole, a proton pump inhibitor, on rhinovirus infection in airways, human tracheal epithelial cells were infected with a major subgroup of rhinoviruses, type 14 rhinovirus. Rhinovirus increased the mRNA expression of intercellular adhesion molecule-1 (ICAM-1) in the cells, the major rhinovirus receptor, and the content of the soluble form of ICAM-1 (sICAM-1) and cytokines in supernatants. Lansoprazole reduced supernatant titers and RNA of rhinovirus, the susceptibility to rhinovirus infection, the ICAM-1 mRNA production, the number and fluorescence intensity of acidic endosomes in the cells, and supernatants sICAM-1 and cytokine concentrations including interleukin-1β. Antibody to interleukin-1β reduced baseline and rhinovirus-induced ICAM-1 production. These results suggest that lansoprazole inhibits rhinovirus infection by reducing ICAM-1 via partly endogenous production of interleukin-1β, and by blocking the rhinovirus RNA entry into the endosomes. Lansoprazole may modulate airway inflammation by reducing the production of cytokines and ICAM-1 in rhinovirus infection.

本文言語English
ページ(範囲)201-210
ページ数10
ジャーナルEuropean Journal of Pharmacology
509
2-3
DOI
出版ステータスPublished - 2005 2 21

ASJC Scopus subject areas

  • Pharmacology

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