The protective effect of pyrroloquinoline quinone and its derivatives against carbon tetrachloride‐induced liver injury of rats

TOSHIHIRO TSUCHIDA, TOSHIFUMI YASUYAMA, KIYOHIRO HIGUCHI, AKIHARU WATANABE, TEIJI URAKAMI, TAKAAKI AKAIKE, KEIZO SATO, HIROSHI MAEDA

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ‐G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl4) in vivo. This effect was observed after an intraperitoneal injection of 5 mg/kg PQQ or OPQ‐G, which was given twice, 10 min and 1 h before CCl4 administration. Pyrroloquinoline quinone protected primary cultured rat hepatocytes from CCl4 toxicity in vitro. This protection was most effective at a concentration of 3 μmol/L PQQ. Pyrroloquinoline quinone derivatives (oxazo pyrroloquinoline, methyl‐thioethyl oxazo pyrroloquinoline and PQQ‐allylester) also protected the hepatocytes from CCl4 toxicity. Pyrroloquinoline quinone and its derivatives inhibited the lucigenin‐enhanced chemiluminescence from isolated hepatocytes initiated by CCl4. These results suggest that eliminating free radicals is one of the protective mechanisms of PQQ and its derivatives against CCl4‐induced liver injury.

本文言語English
ページ(範囲)342-347
ページ数6
ジャーナルJournal of Gastroenterology and Hepatology
8
4
DOI
出版ステータスPublished - 1993 8
外部発表はい

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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