The proline metabolism intermediate Δ 1-pyrroline-5- carboxylate directly inhibits the mitochondrial respiration in budding yeast

Akira Nishimura, Ryo Nasuno, Hiroshi Takagi

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The proline metabolism intermediate Δ 1-pyrroline-5- carboxylate (P5C) induces cell death in animals, plants and yeasts. To elucidate how P5C triggers cell death, we analyzed P5C metabolism, mitochondrial respiration and superoxide anion generation in the yeast Saccharomyces cerevisiae. Gene disruption analysis revealed that P5C-mediated cell death was not due to P5C metabolism. Interestingly, deficiency in mitochondrial respiration suppressed the sensitivity of yeast cells to P5C. In addition, we found that P5C inhibits the mitochondrial respiration and induces a burst of superoxide anions from the mitochondria. We propose that P5C regulates cell death via the inhibition of mitochondrial respiration. Crown

本文言語English
ページ(範囲)2411-2416
ページ数6
ジャーナルFEBS Letters
586
16
DOI
出版ステータスPublished - 2012 7月 30
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「The proline metabolism intermediate Δ 1-pyrroline-5- carboxylate directly inhibits the mitochondrial respiration in budding yeast」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル