The production of 11C-guanidine by the proton irradiation of the liquid ammonia-nitrous oxide system and its use in the synthesis of 11C-pyrimidines

Iwata Ren Iwata, Ido Tatsuo Ido, Tominaga Takeshi Tominaga

    研究成果: Article査読

    9 被引用数 (Scopus)

    抄録

    A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.

    本文言語English
    ページ(範囲)303-308
    ページ数6
    ジャーナルThe International Journal Of Applied Radiation And Isotopes
    32
    5
    DOI
    出版ステータスPublished - 1981 5

    ASJC Scopus subject areas

    • Radiation
    • Nuclear Energy and Engineering
    • Radiology Nuclear Medicine and imaging

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