A new precursor, 11C-guanidine, for the synthesis of 11C-radiopharmaceuticals was produced by the proton irradiation of the liquid NH3N2O system. The optimal ratio of NH3 and N2O was obtained at a 5 μA-30 min irradiation. The maximum yield of 11C-guanidine was about 42% at 69 mmol of N2O per 200 mmol of NH3. The synthesis of 2-amino[2-11C]pyrimidines was carried out by using 11C-guanidine and the optimal reaction conditions were determined. The radiochemical yields of the three 11C-pyrimidines were about 70-100%. It was shown that trimethinium salts are suitable for the synthesis of 11C-pyrimidines from 11C-guanidine.
|ジャーナル||The International Journal Of Applied Radiation And Isotopes|
|出版ステータス||Published - 1981 5|
ASJC Scopus subject areas
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging