The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer

Masaharu Ishida, Makoto Sunamura, Toru Furukawa, Liviu P. Lefter, Rina Morita, Masanori Akada, Shinichi Egawa, Michiaki Unno, Akira Horii

研究成果: Article

9 引用 (Scopus)

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Frequent loss of heterozygosity on the long arm of chromosome 18 is observed in pancreatic cancer. Previous studies suggested the existence of one or more tumor-suppressor genes other than SMAD4 on chromosome 18. To identify the candidate tumor-suppressor gene(s), we compared gene expression by cDNA microarray analyses using a pancreatic cancer cell line Panc-1 and its hybrid cell lines showing suppressed cell growth after introduction of one normal copy of chromosome 18. The microarray analyses identified 38 genes on chromosome 18 that showed differential expressional levels. Among these genes, phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1/APR/NOXA) was identified as one of the candidates for tumor suppressor. Expression vector-mediated introduction of PMAIP1 suppressed cell proliferation, and RNAi-mediated knockdown of PMAIP1 induced recovery of cell growth. These results suggest that PMAIP1 may play an important role in the progression of pancreatic cancer.

元の言語English
ページ(範囲)2576-2582
ページ数7
ジャーナルDigestive Diseases and Sciences
53
発行部数9
DOI
出版物ステータスPublished - 2008 9 1

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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