The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis

Yosuke Funato, Atsushi Yoshida, Yusuke Hirata, Osamu Hashizume, Daisuke Yamazaki, Hiroaki Miki

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Mammalian cells proliferate most efficiently at around pH 7.4. Funato et al. show that cells expressing the oncogene phosphatase of regenerating liver (PRL), which stimulates H+ extrusion by lysosomal exocytosis, shift their optimum pH to acidic 6.5. This phenotype is beneficial for cancer cells to proliferate in the acidic tumor microenvironment.

本文言語English
ページ(範囲)387-397.e8
ジャーナルDevelopmental cell
55
4
DOI
出版ステータスPublished - 2020 11 23

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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