Mammalian cells proliferate most efficiently at around pH 7.4. Funato et al. show that cells expressing the oncogene phosphatase of regenerating liver (PRL), which stimulates H+ extrusion by lysosomal exocytosis, shift their optimum pH to acidic 6.5. This phenotype is beneficial for cancer cells to proliferate in the acidic tumor microenvironment.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology