The nucleosomal binding protein NSBP1 is highly expressed in the placenta and modulates the expression of differentiation markers in placental Rcho-1 cells

Hitoshi Shirakawa, Mark Rochman, Takashi Furusawa, Michael R. Kuehn, Satoru Horigome, Keiichi Haketa, Yumi Sugita, Tomoyuki Inada, Michio Komai, Michael Bustin

    研究成果: Article査読

    13 被引用数 (Scopus)

    抄録

    We report that NSBP1, a nucleosome binding protein that affects the structure of chromatin, is highly expressed in mouse placenta. In Rcho-1 cells, which recapitulate the differentiation of trophoblast giant cells of living placenta, NSBP1 expression is linked to differentiation. Disregulation of NSBP1 protein levels, by either siRNA treatment or by overexpression, alters the expression of several members of the prolactin gene family without affecting the levels of several transcription factors involved in placental differentiation. Our studies identify NSBP1 as a nucleosome binding protein that modulates the expression of prolactin gene family members most likely by inducing changes in chromatin structure.

    本文言語English
    ページ(範囲)651-658
    ページ数8
    ジャーナルJournal of Cellular Biochemistry
    106
    4
    DOI
    出版ステータスPublished - 2009 3月 1

    ASJC Scopus subject areas

    • 生化学
    • 分子生物学
    • 細胞生物学

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