The neuronal architecture of the mushroom body provides a logic for associative learning

Yoshinori Aso, Daisuke Hattori, Yang Yu, Rebecca M. Johnston, Nirmala A. Iyer, Teri T.B. Ngo, Heather Dionne, L. F. Abbott, Richard Axel, Hiromu Tanimoto, Gerald M. Rubin

    研究成果: Article査読

    513 被引用数 (Scopus)

    抄録

    We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell-MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

    本文言語English
    論文番号e04577
    ページ(範囲)e04577
    ジャーナルeLife
    3
    DOI
    出版ステータスPublished - 2014

    ASJC Scopus subject areas

    • 神経科学(全般)
    • 免疫学および微生物学(全般)
    • 生化学、遺伝学、分子生物学(全般)

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