The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD

Naoki Suzuki, Asif M. Maroof, Florian T. Merkle, Kathryn Koszka, Atsushi Intoh, Ian Armstrong, Rob Moccia, Brandi N. Davis-Dusenbery, Kevin Eggan

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Using transgenic mice harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog (3110043O21Rik). Unlike most genes that are mutated in amyotrophic lateral sclerosis (ALS), which are ubiquitously expressed, the C9ORF72 ortholog was most highly transcribed in the neuronal populations that are sensitive to degeneration in ALS and frontotemporal dementia. Thus, our results provide a potential explanation for the cell type specificity of neuronal degeneration caused by C9ORF72 mutations.

本文言語English
ページ(範囲)1725-1727
ページ数3
ジャーナルNature Neuroscience
16
12
DOI
出版ステータスPublished - 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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