The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification

Kazuteru Kono, Yumi Harano, Hideto Hoshino, Masao Kobayashi, David P. Bazett-Jones, Akihiko Muto, Kazuhiko Igarashi, Satoshi Tashiro

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The small ubiquitin-like modifier-1 (SUMO-1) modulates the functions of nuclear proteins by changing their structure and/or subnuclear localization. Several nuclear proteins form dynamic higher order nuclear structures, termed non-chromatin nuclear domains, which are involved in the regulation of nuclear function. However, the role that SUMO modification of the component proteins plays in the regulation of the activity and function of nuclear domains is unclear. Here we demonstrate that nuclear domains formed by Bach2, a transcription repressor, show restricted movement and undergo fusion events upon oxidative stress. Mutation of the SUMO-acceptor lysines in Bach2 alters the behavior of these nuclear foci and results in a decreased frequency of fusion events. We propose that SUMO modification is an important regulatory system for the mobility of the nuclear domains formed by Bach2.

本文言語English
ページ(範囲)903-913
ページ数11
ジャーナルExperimental Cell Research
314
4
DOI
出版ステータスPublished - 2008 2 15

ASJC Scopus subject areas

  • 細胞生物学

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