The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells

Hiroyuki Matsui, Naoto Fukuno, Keiichi Sasaki, Osamu Suzuki, Takayasu Kobayashi, Shinri Tamura

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset of stretch-load and increased proportionally with elongation. However, a marked increase in the phosphorylation of p38 but not JNK was observed when cells were stretched to 4% elongation. These observations raise the possibility that JNK and p38 play different roles in bone remodeling depending on the magnitude and duration of mechanical stretch.

本文言語English
ホスト出版物のタイトル2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
ページ183-186
ページ数4
DOI
出版ステータスPublished - 2007 12 1
イベント2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS - Nagoya, Japan
継続期間: 2007 11 112007 11 14

出版物シリーズ

名前2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS

Other

Other2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
CountryJapan
CityNagoya
Period07/11/1107/11/14

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Networks and Communications
  • Human-Computer Interaction
  • Electrical and Electronic Engineering

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